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The cytotoxicity of three calcium hydroxide-containing root canal sealers (Sealapex, CRCS and Apexit) was tested by using L929 and BHK 21/C13 cells. After setting for 24 h, the sealers were covered with cell suspension. Cytotoxicity was determined by a quantitative technique at 24 h, 48 h and 72 h. All the sealers were found to be cytotoxic. Sealapex showed the highest cytotoxicity, causing a significant decrease in cell density. CRCS was less toxic than Sealapex and more toxic than Apexit. Apexit proved to be the least toxic material.
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Beltes et al. (1995) studied this question.
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