Systemic capsaicin pretreatment worsens trinitrobenzene sulphonic acid-induced colitis but has no effect on colitis induced by ethanol or acetic acid. The influence of capsaicin-sensitive fibres on experimentally-induced colitis seems to depend upon the type of ulcerogenic stimuli in relation to its chronic nature.
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Evangelista et al. (1989) studied this question.
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