Anticancer activity, DNA binding and docking study of M( ii )-complexes (M = Zn, Cu and Ni) derived from a new pyrazine–thiazole ligand: synthesis, structure and DFT

A series of structurally related Zn( ii ), Cu( ii ) and Ni( ii ) complexes of 4-(2-(2-(1-(pyrazin-2-yl)ethylidene)hydrazinyl)-thiazol-4-yl)-benzonitrile ( PyztbH ) have been synthesized and characterized by spectroscopy, single crystal X-ray crystallography and density functional theory (DFT).