Pseudothrombocytopenia and Mexiletine

Letters and Corrections1 May 1984Pseudothrombocytopenia and MexiletineGERD GIRMANN, M.D., HANS PEES, M.D., PAUL GERHARD SCHEURLEN, M.D.GERD GIRMANN, M.D.Search for more papers by this author, HANS PEES, M.D.Search for more papers by this author, PAUL GERHARD SCHEURLEN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-100-5-767_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Fasola and coworkers (1) recently have reported the second case (2) of a mexiletine-associated thrombocytopenia with platelets having been counted in edetic acid-anticoagulated blood. We have observed a hitherto unknown association between mexiletine and pseudothrombocytopenia, in which antibodies in patients' sera (3) react with platelets anticoagulated with edetic acid or other agents (4, 5) causing agglutination and spuriously low platelet counts.In July 1982, a 62-year-old man was hospitalized for thrombocytopenia. After a myocardial infarction in 1981, he received nifedipine, isosorbide dinitrate, and mexiletine (600 mg/d). He had no history of bleeding. After edetic acid treatment, an...References1. FASOLAD'OSUALDODE PANGHERBARDUCCI GFVE. Thrombocytopenia and mexiletine [Letter]. Ann Intern Med. 1984;100:162. LinkGoogle Scholar2. CAMPBELLKELLYSHANKSADGEY NJRA. Long term oral antiarrhythmic therapy with mexiletine. Postgrad Med J. 1977;53(suppl 1):143-5. MedlineGoogle Scholar3. PEGELSBRUYNESENGELFRIETVON DEM BORNE JECA. Pseudothrombocytopenia: an immunologic study on platelet antibodies dependent on ethylene diamine tetra-acetate. Blood. 1982;59:157-61. CrossrefMedlineGoogle Scholar4. CIMO P. Pseudothrombocytopenia. JAMA. 1974;229:766-7. CrossrefMedlineGoogle Scholar5. ONDERWEINSTEINHOYER OAL. Pseudothrombocytopenia caused by platelet agglutinins that are reactive in blood anticoagulated with chelating agents. Blood. 1980;56:177-82. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: First University Medical Center D-6650 Homburg/Saar, West Germany PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEDTA’ya Bağlı Psödotrombositopeni: Olgu SunumuMexiletineSunitinib-associated pseudothrombocytopenia induced by IgM antibodyClinical Pharmacology of Antiarrhythmic DrugsANTIDYSRHYTHMIC DRUGSMolecular characterization of the variable domains of an ?IIb?3-specific immunoglobulin�M ? platelet cold agglutinin in a follicular lymphoma patient with treatment refractory autoimmune thrombocytopenia: idiotypic overlap between ?IIb?3 integrin antibodiesMexiletineOlanzapine-Induced EDTA-Dependent PseudothrombocytopeniaPlatelet cold agglutinins: a flow cytometric analysisPlatelet activation during myocardial ischaemia: A contributory arrhythmogenic mechanismA new type of pseudothrombocytopenia: EDTA-mediated agglutination of platelets bearing Fab fragments of a chimaeric antibodyEdta-dependent pseudothrombocytopenia: A clinical study of 18 patients and a review of the literatureCLASS IA AND CLASS IB ANTIARRHYTHMIC DRUGS - A Review of Their Pharmacokinetics, Electrophysiology, Efficacy, and ToxicityCLASS IA AND CLASS IB ANTIARRHYTHMIC DRUGS ? A Review of Their Pharmacokinetics, Electrophysiology, Efficacy, and ToxicityMexiletineMexiletine for the Management of Ventricular Arrhythmias in Ischemic Heart DiseasePseudothrombocytopenia: a cold autoantibody against platelet glycoprotein GP II bCardiac glycosides and drugs used in dysrhythmias 1 May 1984Volume 100, Issue 5Page: 767-767KeywordsAntibodiesBloodEthylenediaminetetraacetic acidHemorrhageMyocardial infarctionPlatelets Issue Published: 1 May 1984 PDF downloadLoading ...