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January 1, 2004Chemical Communications

Absolute asymmetric synthesis by nucleophilic carbonyl addition using chiral crystals of achiral amides

Masami Sakamoto S. Kobaru Takashi Mino Tsutomu Fujita

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Abstract

Reaction of the chiral crystals of the achiral amides with n-butyllithium in toluene at -80 degrees C gave optically active alcohols in 17-84% ee.

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Sakamoto et al. (2004) studied this question.

synapsesocial.com/papers/6a973dd2e81e629b6aaf61f7 https://doi.org/10.1039/b315729f

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