Phorboid 20‐homovanillates modified on ring C to mimic the constitution and conformation of the ultrapotent vanilloid resiniferatoxin (RTX) and on the AB ring system to suppress the tumour‐promoting potential of the terpenoid core were prepared. Several unexpected reactions were discovered, and the structure‐activity relationships for this class of vanilloid ligands were expanded. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
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