A tandem transannular [4+2] cycloaddition strategy is presented for the synthesis of the class of natural products containing FR182877 (1) and hexacyclinic acid (2). As part of this program, a tandem transannular [4+2] cycloaddition reaction has been employed in the enantioselective synthesis of (−)-FR182877 (1) via the macrocyclic precursor (3).
No takes yet. Share an insight, caveat, or question.
Evans et al. (2002) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: