A One-Step Synthesis of Alkyl 2-Oxo-3-alkenoates from Alkenyl Grignard Reagents and Dialkyl Oxalates

All articles of this category The reaction of alkenyl Grignard reagents with dialkyl oxalates at 80°C in an ether/tetrahydrofuran mixture (1:1) leads to the formation of the corresponding alkyl 2-oxo-3-alkenoates in high yields. Thus a mild and convenient one-step synthesis of 3-isopropenyl-substituted 2-oxoesters is described.