Cationic cyclization of 2‐[7‐(3‐methoxyphenyl)‐(E)‐4‐heptenyl]‐3‐methyl‐2‐cyclopentenol (1c) produced 3‐methoxy‐17‐methyl‐C‐homo‐1,3,5(10),13(17)‐gonatetraene (3c) and its 1‐methoxy isomer 2c. Epoxidation of 3c with tert‐butyl hydroperoxide in the presence of molybdenum hexacarbonyl produced the corresponding 13α, 17α‐epoxide 14 as the major product, which, in three steps, was converted into C‐homo‐1,3,5(10)‐estratriene‐3,17β‐diol (18).
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Groen et al. (1985) studied this question.
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