Conceptually novel homolytic substitutions (SH2) of ClCp2Ti−O bonds with benzylic, secondary and tertiary alkyl radicals are described. The intermediates and crucial transition structures were studied by DFT methods. The resulting atom economical radical tandem reaction can be utilized for the synthesis of structurally complex tetrahydrofurans from simple starting materials and is therefore of interest for natural product synthesis. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
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Gansäuer et al. (2004) studied this question.
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