Key result
Low-intensity treadmill training significantly improved biochemical markers of cardiotoxicity (LDH, CK, glutathione, AST, and ALT) and increased body weight compared to the control group (p<0.05).
Why the study?
Does low-intensity treadmill training improve biochemical markers of cardiotoxicity in doxorubicin-induced cardiotoxicity rat models?
RCT (n=40)
Randomly divided
No
Does low-intensity treadmill training improve biochemical markers of cardiotoxicity in doxorubicin-induced cardiotoxicity rat models?
p-value: p=<0.05
Low-intensity treadmill training protects against doxorubicin-induced cardiotoxicity in rat models by enhancing antioxidant defenses and reducing oxidative stress markers.
Hypothesis-generating for exercise in doxorubicin cardiotoxicity; human trials needed before any practice implications.
Objective: In the present study, we investigated the protective effects of low-intensity treadmill training in doxorubicin-induced cardiotoxicity rat models. Design: Randomized controlled trial. Methods: In this study, we randomly divided them into four groups. The normal group included non-cardiotoxicity normal control (n=10), the control group included non-treadmill training after doxorubicin-induced cardiotoxicity (n=10), the experimental group I included low-intensity treadmill training (3 m/min) after doxorubicin-induced cardiotoxicity (n=10), and the experimental group II included low-intensity treadmill training (8 m/min) after doxorubicin-induced cardiotoxicity (n=10). Rats in the treadmill training group underwent treadmill training, which began at 2 weeks after first intraperitoneal injection. We determined the body weight change for each rat on days 1 and 21. Biochemical markers (lactate dehydrogenase [LDH], creatine kinase [CK], glutathion, aspartate transaminase [AST], and alanine transaminase [ALT]) concentration in the serum change of rats from all four groups was examined at the end of the experiment.
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Ki et al. (2014) conducted an RCT in Doxorubicin-induced cardiotoxicity (n=40). Low-intensity treadmill training vs. Non-treadmill training was evaluated on Biochemical markers (LDH, CK, glutathione, AST, and ALT) concentration in the serum (p=<0.05). Low-intensity treadmill training significantly improved biochemical markers of cardiotoxicity (LDH, CK, glutathione, AST, and ALT) and increased body weight compared to the control group (p<0.05).
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