Key result
Borax treatment significantly decreased malondialdehyde levels (p<0.05) and attenuated the increase in creatine kinase levels in rats with doxorubicin-induced cardiotoxicity.
Why the study?
Boron and boron compounds have beneficial health effects, but the protective effect of borax against doxorubicin-induced cardiotoxicity required determination.
Does borax prevent doxorubicin-induced cardiotoxicity in a rat model?
Does borax prevent doxorubicin-induced cardiotoxicity in a rat model?
p-value: p=<0.05
Borax demonstrates protective effects against doxorubicin-induced cardiotoxicity in rats by modulating oxidative stress markers and reducing creatine kinase levels.
Hypothesis-generating for borax in doxorubicin cardiotoxicity; leaves open any human translation or practice change.
Boron and boron compounds have benefical effects on health of human and animals.This study was designed to determine the protective effect of borax (BX) in doxorubicin (DXR) induced cardiotoxicity in rats. In this study, 20 Wistar-Albino male rats were used. The rats were divided into four groups including 5 rats in each one; control group (standard pellet food + water + normal saline), doxorubicin (3.75 mg/kg/ip, single dose in a week), doxorubicin + borax (3,75 mg/kg/ip + 25 mg/kg/oral/ respectively), and borax (25 mg/kg/oral, single dose in a week). At the end of the experiment, to evaluate antioxidant activity MDA, GSH, CAT, SOD levels determined in blood samples of rats. Besides, CK levels were investigated to determine the effect of doxorubucine on heart tissue. According to the results, MDA levels increased significantly in doxorubucin induced group (p
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ÇELİKEZEN et al. (2021) studied Doxorubicin-induced cardiotoxicity (n=20). Borax vs. Doxorubicin alone was evaluated on Malondialdehyde (MDA) levels (p=<0.05). Borax treatment significantly decreased malondialdehyde levels (p<0.05) and attenuated the increase in creatine kinase levels in rats with doxorubicin-induced cardiotoxicity.
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