A copper-mediated terminal position-selective C(sp(3))-H acetoxylation using a bidentate directing group and AgOAc as an oxidant was achieved. This reaction has high functional group tolerance and is not affected by steric hindrance. The reaction proceeds in excellent yield, even in gram scale, and the directing group can be removed after the reaction. Aromatic C(sp(2))-H acetoxylation also proceeded under similar reaction conditions.
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Wang et al. (2014) studied this question.
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