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Tri- and tetracyclic heterocycles were formed through the tandem cyclization of allenenes 1 upon treatment with an aryl iodide, potassium carbonate, and catalytic [Pd(PPh3)4] (see scheme). The reactivity of the palladium(II) intermediates could be controlled by substitution (R′) at the olefin terminus (Mts=2,4,6-trimethylphenylsulfonyl).
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Ohno et al. (2003) studied this question.
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