A facile palladium‐catalyzed synthesis of acridines has been realized by consecutive C=C double bond formation and C–N cross‐coupling. A variety of functionalized acridines can be accessed from easily available o‐dihalobenzenes and N‐tosylhydrazones in a single operation. This one‐pot protocol has a wide scope with respect to both coupling partners, and provides an efficient route to functionalized acridine derivatives, which are generally difficult to synthesize by previously known methods.
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Huang et al. (2012) studied this question.
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