An enantiopure (salen)aluminum alkoxide complex catalyzes the asymmetric coupling of acylsilanes and cyanoformate esters [Eq. (1) , R=Bn, Et]. The reactions afford unsymmetrical, fully protected malonic acid derivatives that may be elaborated to nonnatural β-amino acid derivatives, and represent the first asymmetric catalytic reactions involving protected cyanohydrin anions.
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Nicewicz et al. (2004) studied this question.
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