A variety of (tetrahydrofuran‐2‐yl)acetates have been prepared based on hydrogenation and subsequent nucleophilic substitutions of 2‐alkylidene‐5‐(hydroxymethyl)tetrahydrofurans. The latter are readily available by cyclization of 1,3‐dicarbonyl dianions (“free dianions”) with epibromohydrin. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
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Freifeld et al. (2006) studied this question.
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