Enantiomerically pure 2‐[2‐(diphenylphosphino)aryl]oxazolines are readily prepared from 2‐bromobenzonitrile by transmetalation with BuLi, subsequent reaction with chloro‐diphenylphosphine and conversion of the resulting phosphinoaryl nitrile to the oxazoline by treatment with a chiral amino alcohol in the presence of ZnCl2. An alternative synthesis is based on the orthometalation of 2‐aryloxazolines followed by reaction with chlorodiphenylphosphine.
No takes yet. Share an insight, caveat, or question.
Koch et al. (1995) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: