Facile access to optically active pyrroloindoles by Fischer-type pyrroloindole synthesis is investigated.The reaction using chiral hydrazines prepared from commercially available chiral amines proceeded with diastereoselective cyclization (up to 70% de), and a short-step conversion of the cycloadducts to (-)-desoxyeseroline and pyrroloindole alkaloids was achieved.
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Nishida et al. (2005) studied this question.
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