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Experimental study demonstrates ring-opening fluorination of bicyclic azaarenes, enabling the synthesis of tertiary carbon-fluorine bonds across diverse functional groups.
]pyridines with electrophilic fluorinating agents, fluorination of the aromatic ring is followed by a ring-opening reaction. Although this overall transformation can be classified as an electrophilic fluorination of an aromatic ring, it is a novel type of fluorination that results in construction of tertiary carbon-fluorine bonds. The present protocol can be applied to a range of bicyclic azaarenes, tolerating azines and a variety of functional groups. Additionally, mechanistic studies and enantioselective fluorination have been examined.
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Komatsuda et al. (2021) studied this question.
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