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PURPOSE: Hypercalcemia is a known complication of childhood malignancies but has never been reported to be associated with Langerhans cell histiocytosis (LCH) in a pediatric patient. PATIENTS AND METHODS: We describe an infant with multisystem LCH who developed hypercalcemia on two occasions. After being placed on indomethacin, the hypercalcemia did not recur despite disease progression. CONCLUSION: Hypercalcemia may complicate LCH. If it is demonstrated, indomethacin should be considered as a treatment.
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McLean et al. (1996) studied this question.
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