Enantiomerically pure BIPHOS was obtained by spontaneous resolution through the crystallization of a racemic mixture, without the use of chemical or physical chiral auxiliaries, and was used in the synthesis of the enantiomerically pure complex [PdCl2(biphos)] (see scheme). The complex proved to be efficient in catalytic asymmetric allylic substitutions with 80 % ee.
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Tissot et al. (2001) studied this question.
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