Identification of Potent Ras Signaling Inhibitors by Pathway‐Selective Phenotype‐Based Screening

Blocking the path to cancer: Application of efficient strategy for a phenotype-based screening of compound libraries to a library of sulindac-derived compounds (see scheme) yielded new inhibitors of the tumor-relevant Ras signal transduction pathway with high fidelity (as shown by microscopy). The results underline the advantage of using biologically prevalidated compound classes in chemical biology research.