Convergent Asymmetric Synthesis of (+)‐Aureothin Employing an Oxygenase‐Mediated Resolution Step

Need an enzymatic push? The desymmetrization of α,α′-dimethoxy-γ-pyrone allows the convergent and rapid preparation of the complete carbon skeleton of (+)-aureothin (see scheme). The final step in the synthesis of the target molecule is the regiodivergent parallel kinetic resolution promoted by cytochrome P450 monooxygenase AurH to deliver the enantiopure natural product.