A number of 1‐alkyl‐2‐carbomethoxyazetidines have been prepared from the reaction of primary amines with α,γ‐dibromoearbonyl compounds. A series of base catalyzed reactions performed on selected cis, trans‐1‐alkyl‐2‐carbomethoxy‐4‐alkyl(aryl)azetidines reveal the cis isomer to be of greater thermodynamic stability. Furthermore, base catalyzed deuterium exchange studies suggest this to be the case.
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Kulkarni et al. (1976) studied this question.
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