Key result
Thoracic irradiation of 20 Gy in rats increased plasma ANP to 140% of control values from 3 months onwards, suggesting it as a marker for early stage radiation-induced cardiac dysfunction.
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May support ANP as early marker of radiation cardiotoxicity in rats; hypothesis-generating and requires clinical validation.
Cheryl Persons (1996) studied radiation-induced heart disease. Thoracic irradiation vs. Control was evaluated on Plasma and myocardial atrial natriuretic peptide (ANP) concentrations. Thoracic irradiation of 20 Gy in rats increased plasma ANP to 140% of control values from 3 months onwards, suggesting it as a marker for early stage radiation-induced cardiac dysfunction.
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