Addition of long-acting beta2 agonists or long-acting muscarinic antagonists versus doubling the dose of inhaled corticosteroids (ICS) in adolescents and adults with uncontrolled asthma with medium dose ICS: a systematic review and network meta-analysis

This is the authors' abstract. We don't add key points for this paper.

Objectives This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To conduct NMAs to compare effectiveness and tolerability of adding a LABA or LAMA to existing ICS therapy versus doubling the dose of ICS in adolescents and adults with uncontrolled asthma who have been treated with or are eligible for LABA/ICS combination therapy.