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The imines of Ellman's tert ‐butylsulfinamides have become one of the elementary substrates for the construction of chiral precursors and complex organic molecules. This article reports a mechanochemical access to imines of chiral tert ‐butylsulfinamides with a variety of aldehydes using solid acid catalyst, perchloric acid‐silica (HClO 4 ⋅SiO 2 ) at innocuous reaction environs. The conversion can be carried out at ambient temperature under solvent and metal‐free conditions by (hand) grinding the contents in a mortar at open‐air. The current protocol is highly economical, allows large‐scale preparation, offers a very good to nearly quantitative yields of imines in short reaction times with no product racemization and doesn′t necessitate the moisture‐free conditions.
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Appa et al. (2018) studied this question.
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