Key result
Obesity during pregnancy was associated with baseline cognitive impairment, which significantly worsened after cesarean delivery under spinal anesthesia (MOS score decreased to 24.3, p=0.004).
Why the study?
Anesthesia and pregnancy-related obesity are both associated with cognitive impairment, anxiety, and depression, prompting evaluation of the effect of obesity during regional anesthesia.
Does obesity worsen cognitive function, anxiety, and depression in pregnant women undergoing spinal anesthesia for cesarean section?
Observational (n=70)
Does obesity worsen cognitive function, anxiety, and depression in pregnant women undergoing spinal anesthesia for cesarean section?
Absolute Event Rate: 24.3% vs 25.6%
p-value: p=0.004
Obesity during pregnancy is associated with worse baseline cognitive function, anxiety, and depression, and further cognitive decline following spinal anesthesia for cesarean section.
May warrant closer cognitive monitoring in obese parturients after cesarean spinal anesthesia; leaves open whether obesity independently drives decline versus confounders.
Background. A number of studies have associated aggravation of cognitive impairment, anxiety and depression in pregnant women with anesthesia. In addition, obesity during pregnancy itself is associated with an increased risk of developing these complications. The objective was to study the effect of obesity on cognitive function, anxiety and depression in pregnant women during regional anesthesia. Materials and methods. The study included 70 pregnant women who were admitted for planned delivery. Patients were divided into two groups: obese pregnant women (BMI≥ 30) (n = 35) and pregnant women with normal weight (BMI < 30) (n = 35). All patients underwent surgery under spinal anesthesia. The indicators of cognitive function, anxiety, and depression were evaluated using specially selected tests before surgery and on the third day of the postoperative period. Results. The development of obesity during pregnancy was accompanied by an impairment of cognitive functions. After surgery, in the BMI≥ 30 group, cognitive function according to the MOS test decreased from 25.1 (25.9; 24.2) to 24.3 (25.2; 23.4) points (p = 0.004), and in the BMI < 30 group, there were no statistical differences – 26.3 (27.1; 25,5) and 25.6 (26.5; 24.7) points (p = 0.071). In addition, the baseline indicators of anxiety and depression in obese pregnant women were higher in comparison with pregnant women with normal weight (p < 0.001). Performing a cesarean section under spinal anesthesia in all patients led to a decrease in anxiety and an increase in depression in the BMI≥ 30 group from 7.2 (8.1; 6.7) to 6.9 (7.5; 6.3) points (p = 0.004), and in the BMI < 30 group – from 6.5 (6.8; 6.2) to 6.1 (6.5; 5.7) points (p = 0.038). Conclusion. The presence of obesity during pregnancy was revealed in combination with impairment of cognitive functions even before surgery, after delivery under spinal anesthesia, cognitive dysfunction increased.
No takes yet. Share an insight, caveat, or question.
Chernykh et al. (2023) conducted an observational in Pregnancy (n=70). Obesity (BMI ≥ 30) vs. Normal weight (BMI < 30) was evaluated on Cognitive function (MOS test score) on the third postoperative day (p=0.004). Obesity during pregnancy was associated with baseline cognitive impairment, which significantly worsened after cesarean delivery under spinal anesthesia (MOS score decreased to 24.3, p=0.004).
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: