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The synthesis of 3,4‐dihydro‐4‐oxothieno[2,3‐d]pyrimidine‐2‐carboxylates via acid catalyzed reactions of various 2‐aminothiophene‐3‐carboxylates with activated nitriles is presented. The requisite thiophenes were prepared regioselectively by methods which represent improvements over previously published procedures.
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Madding et al. (1987) studied this question.
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