A Linker Scaffold to Present Dimers of Pharmacophores Prepared by Solid-Phase Syntheses

Mimicry or disruption of protein–protein interactions requires the presentation of pharmacophores to match discontinuous sites on the macromolecular surfaces. The linker shown here was designed to achieve this. The orthogonal protecting groups on the linker allow it to be differentially functionalized, then cleaved from the resin using reagents that will not interfere with biological assays. Fmoc=9-fluorenylmethoxycarbonyl, Boc=tert-butoxycarbonyl.