Key result
Metabolic dysfunction-associated steatotic liver disease (MASLD) is an independent risk factor for all-cause mortality and cardiovascular disease, acting as a central player in the CKM syndrome.
Why the study?
MASLD has not been afforded parity alongside other cardiometabolic non-communicable disorders, including cardiovascular-kidney-metabolic (CKM) syndrome, despite being an independent risk factor for cardiovascular disease and all-cause mortality.
Recognizing MASLD as an integral component of the cardiovascular-kidney-metabolic (CKM) syndrome is crucial for comprehensive interdisciplinary patient care.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide, with a reach extending beyond the liver to include other metabolic syndrome-related disorders. Cardiovascular disease and type 2 diabetes mellitus are recognised non-communicable disorders and often downstream complications of MASLD and share similar risk factors. However, MASLD has not been afforded parity alongside other cardiometabolic non-communicable disorders, including the cardiovascular-kidney-metabolic (CKM) syndrome. Notably, MASLD is an independent risk factor for increased all-cause mortality and cardiovascular disease. This review aims to position MASLD as a central player in lipid metabolism, systemic inflammation, and insulin resistance, which are key features in the pathogenesis of the CKM syndrome. MASLD is an integral player enjoining the liver to the CKM syndrome as the liver-CKM syndrome. Increasing interdisciplinary awareness of this will enhance patient care.
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Goodheart et al. (2025) conducted a review in Metabolic dysfunction-associated steatotic liver disease (MASLD) and cardiovascular-kidney-metabolic (CKM) syndrome. Metabolic dysfunction-associated steatotic liver disease (MASLD) was evaluated. Metabolic dysfunction-associated steatotic liver disease (MASLD) is an independent risk factor for all-cause mortality and cardiovascular disease, acting as a central player in the CKM syndrome.
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