Hermann Friedberg's case report: an early description of CLOVES syndrome

Alomari AI, Thiex R, Mulliken JB. Hermann Friedberg's case report: an early description of CLOVES syndrome. CLOVES syndrome is a recently described overgrowth disorder with complex vascular anomalies. Careful analysis of the case report by the German physician Hermann Friedberg “gigantism of the right lower limb” published in 1867 revealed that the report probably represents one of the first written accounts of CLOVES syndrome.