Acquired high-titer factor VIII inhibitor: fatal bleeding despite multimodal treatment including rituximab preceded by multiple plasmaphereses

Acquired factor VIII (FVIII) inhibitors can cause life-threatening bleeding. Rapid restoration of coagulation is vital. Therapeutic approaches include factor substitution,[1][1],[2][2]immunosuppression (eg, steroids, cyclophosphamide[3][3]), and plasmapheresis.[4][4] A novel treatment option is