Key result
Wide local excision with a resection margin of ≥ 20 mm successfully treated a giant subcutaneous leiomyosarcoma in the inguinal region, with the patient remaining disease-free at 5 years and 8 months.
Case Report (n=1)
No
A wide local excision with a resection margin of ≥ 10 mm is recommended for giant subcutaneous leiomyosarcoma to prevent recurrence.
Supports wide excision margins in rare giant subcutaneous leiomyosarcoma; single case leaves optimal width and generalizability open.
BACKGROUND: Subcutaneous leiomyosarcoma is a rare condition that accounts for 1% to 2% of all superficial soft tissue malignancies. Approximately 10% of cases arise in the trunk, although the extremities are the most commonly affected. CASE PRESENTATION: We report herein the case of a 31-year-old man with a subcutaneous leiomyosarcoma, measuring 124 x 105 mm, arising in the left inguinal region. A wide local excision (with a resection margin >/= 20 mm) was performed. Histological examination of the resected specimen revealed a leiomyosarcoma with high cellularity and two mitoses per 10 high-power fields. The patient remains well with no evidence of disease 5 years and 8 months after the operation. CONCLUSION: This is the first reported case of subcutaneous leiomyosarcoma arising in the inguinal region and also one of the largest tumors reported. The experience of this case and a review of the English-language literature (PubMed, National Library of Medicine, Bethesda, MD, USA) suggest that a resection margin of >/= 10 mm is recommended when excising this rare tumor.
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Yajima et al. (2005) conducted a case report in Subcutaneous leiomyosarcoma (n=1). Wide local excision was evaluated on Disease-free survival. Wide local excision with a resection margin of ≥ 20 mm successfully treated a giant subcutaneous leiomyosarcoma in the inguinal region, with the patient remaining disease-free at 5 years and 8 months.
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