Key result
Higher tumor grade in head and neck pleomorphic dermal sarcomas was associated with significantly lower 5-year overall survival rates, declining from 69% for grade I to 42% for grade IV (P=0.03).
Why the study?
The study was conducted to examine survival by tumor grade in patients with pleomorphic dermal sarcomas of the head and neck.
Does tumor grade affect 5-year overall survival in patients with head and neck pleomorphic dermal sarcomas?
Cohort (n=270)
Yes
Does tumor grade affect 5-year overall survival in patients with head and neck pleomorphic dermal sarcomas?
p-value: p=0.03
Survival rates for head and neck pleomorphic dermal sarcomas significantly decline with higher tumor grade.
May guide prognostic counseling in head and neck PDS; leaves open prospective validation of grade-based stratification.
Objective To examine survival by tumor grade of pleomorphic dermal sarcomas (PDS) of the head and neck (H&N) and review a scalp PDS case. Methods Patients in the Surveillance, Epidemiology, and End Results (SEER) database were included from 1980 to 2016 based on a diagnosis of H&N PDS. Survival estimates were performed using Kaplan–Meier analysis. Additionally, a case of a grade III H&N PDS is presented. Results Two hundred‐seventy cases of PDS were identified. The mean age at diagnosis was 75.1 years (SD: 13.5). Two hundred‐thirty‐four (86.7%) patients were male. Eighty‐seven percent of patients received surgery as a part of their care. The 5‐year overall survival rates for grades I, II, III, and IV PDSs were 69%, 60%, 50%, and 42%, respectively (P = 0.03). Conclusions H&N PDS occurs most commonly in older‐age males. Surgical management is frequently a part of H&N PDS care. Survival rates significantly decline based on tumor grade.
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Janz et al. (2022) conducted a cohort in Head and neck pleomorphic dermal sarcomas (n=270). Tumor grade vs. Lower tumor grades was evaluated on 5-year overall survival (p=0.03). Higher tumor grade in head and neck pleomorphic dermal sarcomas was associated with significantly lower 5-year overall survival rates, declining from 69% for grade I to 42% for grade IV (P=0.03).
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