Key result
The collagen receptor DDR2 is expressed in the atrioventricular canal during epithelial-mesenchymal transformation in both activated endothelial and migrating mesenchymal cells in vivo.
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Discoidin Domain Receptor 2 (DDR2) is a receptor tyrosine kinase which has been shown to regulate cell migration upon binding its ligand, collagen. Expression studies determined that DDR2 mRNA and protein are present in the atrioventricular canal during epithelial-mesenchymal transformation (EMT) and the receptor is expressed in both activated endothelial and migrating mesenchymal cells in vivo.
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Goldsmith et al. (2009) studied this question. The collagen receptor DDR2 is expressed in the atrioventricular canal during epithelial-mesenchymal transformation in both activated endothelial and migrating mesenchymal cells in vivo.
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