SummaryThe mechanism of the radioprotective action of cyanide has been investigated with rat-thymocyte suspensions, cultured human-kidney cells and with mice.Cyanide does not protect cells in vitro. In the thymocyte system, cyanide has instead a slight radiosensitizing action. The presence of cyanide after the irradiation causes an inhibition of the development of eosin permeability.In mice, cyanide produces a hypoxia of the spleen and bone-marrow. This hypoxia explains the protection against a lethal dose of x-rays.
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Meer et al. (1962) studied this question.
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