Autopsy findings of Coxsackie B viral myocarditis suggest age-related differences in inflammatory response, with adults showing more intensive and prolonged inflammation compared to infants.
Autopsy cases do not yet inform clinical decisions on viral myocarditis; leaves open age-dependent inflammatory patterns requiring validation.
Autopsy cases of myocarditis caused by Coxsackie viruses in two infants, aged 5 years and 10 months and 12 years, and two adults, aged 24 years and 45 years, were presented. Of the four cases, three revealed a rise in serum neutralization titer to Cox B,4 virus and one to both Cox B2 and Cox B4 viruses. Compared with the adult cases, the 2 infant cases showed less inflammatory response with relatively prominent hypertrophy in the heart. Both of the adult cases revealed intensive inflammatory reaction. Extensive inflammatory cell infiltration remained in one of the adult cases though the case survived about 4 years after manifestation of the infection, suggesting possible involvement of immunological factors.
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Tanimura et al. (1980) studied this question.
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