Selective Palladium‐Catalyzed Domino Heck/Buchwald–Hartwig Arylations of N‐Glycosylcinnamamides: An Efficient Route to 4‐Aryl‐N‐glycosylquinolin‐2‐ones

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An efficient and selective domino Heck/Buchwald–Hartwig arylations of readily available N‐glycosylcinnamamides with aryl iodides have been established. Using palladium(II) acetate as a catalyst, potassium acetate as the base and tetrabutylamonium bromide as an additive in dioxane, the protocol proved to be general, and a variety of 4‐aryl‐N‐glycosylquinolin‐2‐ones has been prepared in good yields with exclusive α‐ or β‐selectivity. magnified image