Granulocytic leukemia and reticulum cell sarcoma

Two cases of granulocytic leukemia associated with reticulum cell sarcoma are reported. Reticulum cell sarcoma was diagnosed in one patient from lymph node biopsy during life and from histological evaluation of bone marrow sections postmortem; studies of peripheral blood and bone marrow aspirated 8 days before death, however, revealed changes of acute granulocytic leukemia. Reticulum cell sarcoma was diagnosed in the second patient 7 months before he developed the peripheral blood and bone marrow findings of chronic granulocytic leukemia. The relationship between these 2 entities is discussed and the authors suggest that they may represent the same basic disease process studied through 2 different morphologic methods.