Key result
First trimester exposure to selective serotonin reuptake inhibitors was associated with a twofold increased risk of septal heart defects, particularly with citalopram or sertraline.
Why the study?
Does first trimester exposure to SSRIs increase the risk of septal heart defects in neonates?
Does first trimester exposure to SSRIs increase the risk of septal heart defects in neonates?
First trimester exposure to certain SSRIs, particularly citalopram, sertraline, or multiple types, is associated with a twofold increased risk of septal heart defects in neonates.
In a population study, Pedersen and colleagues found a twofold increased risk of septal heart defects after first trimester exposure to selective serotonin reuptake inhibitors (SSRIs).1 The prevalence increased with citalopram or sertraline but not paroxetine or fluoxetine, and exposure to more than one type of SSRI posed the greatest …
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Klinger et al. (2009) studied this question. First trimester exposure to selective serotonin reuptake inhibitors was associated with a twofold increased risk of septal heart defects, particularly with citalopram or sertraline.
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