Key result
Voluntary climbing exercise significantly decreased arterial ET-1 protein levels and prevented bone loss (p<0.05) in ovariectomized rats, whereas swimming suppressed endothelial dysfunction but did not prevent bone loss.
Why the study?
Does voluntary climbing or swimming exercise prevent endothelial dysfunction and bone loss in ovariectomized rats treated with vitamin D3 and nicotine?
Does voluntary climbing or swimming exercise prevent endothelial dysfunction and bone loss in ovariectomized rats treated with vitamin D3 and nicotine?
Different exercise modalities have distinct effects in a postmenopausal rat model; climbing resistance exercise prevents both bone loss and endothelial dysfunction, while swimming only improves endothelial function.
Exercise effects appear modality-specific in this model; leaves open clinical translation for postmenopausal women.
PURPOSE: Several epidemiological studies have demonstrated that there are positive correlations between vascular disorders and bone loss in postmenopausal women. The aim of the present study was to examine the effect of different types of exercise (e.g., climbing and swimming) for preventing endothelial dysfunction of arteries and bone loss in ovariectomized rats. METHODS: Twenty Sprague-Dawley female rats were randomly divided into three groups: ovariectomy (OVX) plus treatment with vitamin D3 and nicotine (VDN) (control rats [Con], n = 7), which is an animal model for endothelial dysfunction and bone loss; voluntary climbing resistance exercise with OVX plus VDN (climbing rats [Clim], n = 6), and swimming exercise with OVX plus VDN (swimming rats [Swim], n = 7). The period of exercise training was 8 weeks. RESULTS: The endothelin-1 (ET-1) protein levels were significantly lower in the Clim and Swim groups than in the Con. The endothelial nitric oxide synthase protein levels were significantly higher in the Swim group than in the Con, but they did not differ between the Clim and Con groups. The cortical bone mineral density in the tibia and breaking energy of the femur were significantly higher in the Clim group than in the Con, but this positive effect was not seen in the Swim group. CONCLUSION: Voluntary climbing exercise decreased arterial ET-1 protein levels and prevented bone loss in a postmenopause-model rat combining OVX and VDN. Conversely, swimming suppressed endothelial dysfunction of the arteries but did not prevent bone loss. Thus, the type of exercise should be cautiously chosen for enhancing vascular function and bone status, especially in females after menopause.
No takes yet. Share an insight, caveat, or question.
Park et al. (2014) studied Endothelial dysfunction and bone loss (ovariectomy + vitamin D3 and nicotine model) (n=20). Voluntary climbing resistance exercise and swimming exercise vs. No exercise (control) was evaluated on Arterial ET-1 protein levels and bone mineral density (p=<0.05). Voluntary climbing exercise significantly decreased arterial ET-1 protein levels and prevented bone loss (p<0.05) in ovariectomized rats, whereas swimming suppressed endothelial dysfunction but did not prevent bone loss.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: