Design and Synthesis of a Taxoid Library Using Radiofrequency Encoded Combinatorial Chemistry

Radiofrequency encoded combinatorial (REC) chemistry is a recently developed nonchemical encoding strategy in library synthesis. Encoded chemical libraries of complex molecular structures like Taxol can be constructed employing the noninvasive REC strategy and novel solid phase synthesis techniques, as demonstrated by the synthesis of the first 400-membered taxoid library in a discrete format and in quantities of multimilligrams/member.