Key result
In dogs, sympathomimetic drugs with 2 or 3 hydroxyl groups caused depressed ST segments and tall peaked T waves, while those with 1 or 0 hydroxyl groups caused coved ST segments and inverted T waves.
Population
Unanaesthetized dogs and open-chest animals
Comparison
Infusion of sympathomimetic drugs into the left… vs Different structural classes of sympathomimetic…
Design
Preclinical
Authors
Loading...
May inform preclinical sympathomimetic screening; leaves open translation to human repolarization or arrhythmia risk.
The structural characteristics of sympathomimetic drugs determine their specific effects on ventricular repolarization and electrocardiographic ST-T wave changes in a canine model.
Sparks et al. (1970) studied this question. Sympathomimetic drugs was evaluated on Electrocardiographic responses. In dogs, sympathomimetic drugs with 2 or 3 hydroxyl groups caused depressed ST segments and tall peaked T waves, while those with 1 or 0 hydroxyl groups caused coved ST segments and inverted T waves.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: