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Aging limits the number of divisions available to cells and the chronological life span of nondividing cells. In his Perspective, [Rine][1] discusses recent findings that caloric restriction, SIR2 , and its molecular cousins, play conserved roles in aging. However, expectations of a simple unified model linking caloric restriction and aging through Sir2 protein's NADcofactor are now on hold. [1]: http://www.sciencemag.org/cgi/content/full/310/5751/1124
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Jasper Rine (2005) studied this question.
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