Answers are grounded in this paper and cite their sources.
RNA granules have been observed in different organisms, cell types and under different conditions, and their formation is crucial for the mRNA life cycle. However, very little is known about the molecular mechanisms governing their assembly and disassembly. The aggregation-prone LSCRs (low-sequence-complexity regions), and in particular, the polyQ/N-rich regions, have been extensively studied under pathological conditions due to their role in neurodegenerative diseases. In the present review, we discuss recent in vitro, in vivo and computational data that, globally, suggest a role for polyQ/N regions in RNA granule assembly.
No takes yet. Share an insight, caveat, or question.
Castilla‐Llorente et al. (2014) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: