Key result
Intravenous and oral thiamine and copper supplementation led to complete neurological recovery over 18 months in a 26-year-old female with severe myelopathy and polyneuropathy following bariatric surgery.
Why the study?
The frequency, clinical course, and prognosis of neurological sequelae following bariatric surgery remain obscure.
Case Report (n=1)
Severe central and peripheral neuropathy following bariatric surgery due to thiamine and copper deficiency can be completely reversed with timely pharmacological and rehabilitative treatment.
This is the authors' abstract. We don't add key points for this paper.
The frequency, clinical course, and prognosis of the neurological sequelae following bariatric surgery remain obscure and continue to be a subject of medical research. We present the case of a 26-year-old female who underwent sleeve gastrectomy for the treatment of obesity and demonstrated progressive neurological deficits within months of her procedure. Extensive testing revealed very low thiamine and copper levels, peripheral polyneuropathy, and spinal cord lesions on imaging. She was treated with intravenous copper and thiamine and was admitted to the rehabilitation unit. Eighteen months following her admission, she achieved complete recovery. Previous studies have reported neurological complications following bariatric surgery in 1.1-8.6% of cases. Some of the most common nutritional deficiencies involve copper, iron, calcium, magnesium, and vitamins B1, B12, D, and E. Patients may experience central and peripheral neurological deficits following bariatric surgery. Fortunately, a path to recovery exists and it involves both pharmacological and rehabilitative treatment.
Answers are grounded in this paper and cite their sources.
Recovery possible in severe post-bariatric neuropathy with copper-thiamine repletion; leaves open generalizability beyond single cases.
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Jindal et al. (2021) conducted a case report in Cervical Myelopathy and Peripheral Polyneuropathy (n=1). Thiamine and copper supplementation was evaluated on Neurological recovery. Intravenous and oral thiamine and copper supplementation led to complete neurological recovery over 18 months in a 26-year-old female with severe myelopathy and polyneuropathy following bariatric surgery.
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