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September 25, 2017Proceedings of the National Academy of SciencesOpen Access

Physical proximity of chromatin to nuclear pores prevents harmful R loop accumulation contributing to maintain genome stability

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Authors

FGFrancisco García-BenítezHGHélène GaillardCentro Andaluz de Biología Molecular y Medicina RegenerativaAAAndrés AguileraCentro Andaluz de Biología Molecular y Medicina Regenerativa

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García-Benítez et al. (2017) studied this question.

synapsesocial.com/papers/6a97770cd08ffd74dfc613a7https://doi.org/10.1073/pnas.1707845114
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Also Consider

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  1. 1The Npl3 hnRNP prevents R-loop-mediated transcription–replication conflicts and genome instability2013 · 91 citations
  2. 2Tho1, a Novel hnRNP, and Sub2 Provide Alternative Pathways for mRNP Biogenesis in Yeast THO Mutants2006 · 53 citations
  3. 3R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants2012 · 229 citations
  4. 4Genome-Wide Profiling of Yeast DNA:RNA Hybrid Prone Sites with DRIP-Chip2014 · 234 citations