Key result
Prospective surveillance of 245 poliomyelitis cases in Karachi demonstrated that wild polio type 1 was the dominant serotype, predominantly affecting children aged 6 months to 2 years.
Observational (n=245)
No
The study demonstrated that Pakistan was endemic for wild poliovirus during 1990-1993, highlighting the need for aggressive preventive measures.
Between October 1989 and September 1993, 245 cases of poliomyelitis visited the Department of Pediatrics, Civil Hospital Karachi, Pakistan. The majority of them were between 6 months and 2 years of age and the epidemic occurred during the hot season. The dominant serotype was polio type 1. All of the polioviruses isolated from the patients were wild type. Virological studies also disclosed that enteroviruses other than polioviruses were prevalent among healthy children as well as diarrheal and polio patients. Serodiagnosis by poliovirus-specific immunoglobulin M antibody tests using the capture enzyme-linked immunosorbent assay method were in good agreement with the results of virus isolation. The present study demonstrated that Pakistan is a region endemic for wild poliovirus and more aggressive preventive measures are needed to eradicate poliomyelitis from the region.
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Isomura et al. (1996) conducted an observational in Poliomyelitis (n=245). Prospective surveillance of 245 poliomyelitis cases in Karachi demonstrated that wild polio type 1 was the dominant serotype, predominantly affecting children aged 6 months to 2 years.
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